CaltechAUTHORS
Published November 12, 2007 | Version Supplemental Material
Journal Article Open

Recognition of "mirror-image" DNA by small molecules

Creators

  • 1. ROR icon California Institute of Technology
  • 2. ROR icon Ludwig-Maximilians-Universität München

Abstract

May the force be with you: "Mirror-image" hairpin polyamides distinguish the L enantiomer of DNA (L-DNA) in the presence of natural DNA (D-DNA). This specificity is investigated by a molecular force balance at a single-molecule level. The "DNA balance" allows the measurement of rupture forces of match/mismatch diastereomeric complexes in a single experiment.

Additional Information

© 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: July 6, 2007; Revised: August 8, 2007; Published online: September 26, 2007. Support was provided by the National Institutes of Health, the Deutsche Forschungsgemeinschaft, and the Fonds der Chemischen Industrie. C.D. is grateful to the Alexander von Humboldt foundation for a postdoctoral fellowship. D.H. is grateful to the Elite Network of Bavaria (IDK-NBT) for a doctoral fellowship.

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Supplemental Material - z703007_s.pdf

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Additional details

Identifiers

Eprint ID
66742
Resolver ID
CaltechAUTHORS:20160509-104245486

Funding

NIH
Deutsche Forschungsgemeinschaft (DFG)
Fonds der Chemischen Industrie
Alexander von Humboldt Foundation
Elite Network of Bavaria (IDK-NBT)

Dates

Created
2016-05-17
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Updated
2021-11-11
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