Published November 7, 2019
| Version Supplemental Material
Journal Article
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Cu-Catalysed carboxylation of aryl boronic acids with CO₂
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1.
Peking University
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2.
Division of Chemistry
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3.
California Institute of Technology
Abstract
A copper/N-heterocyclic carbene (NHC) catalysed carboxylation of aryl boronic acids under one atmospheric pressure of CO₂ has been developed. A wide range of aryl boronic acids was transformed into benzoic acid derivatives in moderate to high yields. The carboxylation method shows excellent functional group compatibility, and sensitive functional groups such as carbonyls, esters, and nitriles were tolerated. Mechanistic studies revealed the vital role of the base in promoting the transmetalation step for this copper-catalysed carboxylation.
Additional Information
© 2019 the Partner Organisations. The article was received on 18 Aug 2019, accepted on 17 Sep 2019 and first published on 23 Sep 2019. O. N. is grateful to Peking University for the Boya Postdoctoral Fellowship. The project is supported by the Natural Science Foundation of China (Grant 21772003). We also thank Peking University for a start-up fund. This work was partially funded by the BHP-PKU CCUS project supported by BHP Billiton. There are no conflicts to declare.Attached Files
Supplemental Material - c9qo01023h1_si.pdf
Files
c9qo01023h1_si.pdf
Additional details
Identifiers
- Eprint ID
- 98852
- Resolver ID
- CaltechAUTHORS:20190925-102409660
Funding
- Peking University
- Natural Science Foundation of China
- 21772003
- BHP Billiton
Dates
- Created
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2019-09-25Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field