CaltechAUTHORS
Published February 17, 2011 | Version Published
Book Section - Chapter Open

Millimeter wave-induced changes in membrane properties of leech Retzius neurons

Creators

  • 1. ROR icon Huntington Medical Research Institutes
  • 2. ROR icon University of Southern California
  • 3. ROR icon California Institute of Technology

Contributors

Abstract

This study evaluated a novel method for modulation of neuronal excitability using non-invasive delivery of millimeter waves. Millimeter waves at 60 GHz and incident power density of 100-600 μW/cm^2 were applied to three intact segmental ganglia of the adult leach, and intracellular neuronal activity was recorded from the Retzius neurons using intracellular glass electrode. Transient dosedependent increase in the plasma membrane permeability was observed. In addition, in one of the examined neurons, a decrease in the neuronal firing rate was also evident. The results provide strong evidence for the feasibility of modulating neuronal excitability using non-invasive delivery of millimeter waves, and will be explored further for applications in basic neuroscience and treatment of neurological disorders.

Additional Information

© 2011 SPIE Society of Photo-Optical Instrumentation Engineers.

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Additional details

Identifiers

Eprint ID
71631
Resolver ID
CaltechAUTHORS:20161031-141459277

Dates

Created
2016-11-01
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Updated
2021-11-11
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Caltech Custom Metadata

Series Name
Proceedings of SPIE
Series Volume or Issue Number
7883