Time-reversed ultrasonically encoded optical focusing in biological tissue
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1.
Washington University in St. Louis
Abstract
We report an experimental investigation of time-reversed ultrasonically encoded optical focusing in biological tissue. This technology combines the concepts of optical phase conjugation and ultrasound modulation of diffused coherent light. The ultrasonically encoded (or tagged) diffused light from a tissue sample is collected in reflection mode and interferes with a reference light in a photorefractive crystal (used as a phase conjugation mirror) to form a hologram. Then a time-reversed copy of the tagged light is generated and traces back the original trajectories to the ultrasonic focus inside the tissue sample. With our current setup, we can achieve a maximum penetration depth of 5 mm in a chicken breast sample and image optical contrasts within a tissue sample with a spatial resolution approximately equaling 1/√2 of the ultrasound focal diameter.
Additional Information
© 2012 SPIE. Paper 11563 received Sep. 30, 2011; revised manuscript received Jan. 20, 2012; accepted for publication Jan. 23, 2012; published online Mar. 8, 2012; corrected Mar. 19, 2012. This research is sponsored in part by the National Academies Keck Futures Initiative grant IS 13 and the National Institute of Health through grants R01 EB000712 and U54 CA136398. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.Errata
This article was originally published in Vol. 17 of the Journal of Biomedical Optics on 8 March 2012 in the wrong section of the table of contents and with an incorrect citation identifier (CID) of 036001. The paper was removed and republished online with the correct CID of 030506 on 19 March 2012. This change was made in order for the paper to appear under the correct section heading, "JBO Letters." For more information on the use of CIDs in JBO, see http://spiedigitallibrary.org/jbo/citation_formatAttached Files
Published - JBO_17_3_030506.pdf
Erratum - 049802_1.pdf
Files
049802_1.pdf
Additional details
Identifiers
- PMCID
- PMC3380942
- Eprint ID
- 69683
- Resolver ID
- CaltechAUTHORS:20160816-155345267
Related works
- Describes
- 10.1117/1.JBO.17.4.049802 (DOI)
- Is variant form of
- PMC4098039 (PMCID)
Funding
- National Academies Keck Futures Initiative
- IS 13
- NIH
- R01 EB000712
- NIH
- U54 CA136398
Dates
- Created
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2016-08-16Created from EPrint's datestamp field
- Updated
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2023-06-01Created from EPrint's last_modified field