CaltechAUTHORS
Published June 2009 | Version Published
Journal Article Open

Enantioselective γ-lactam synthesis via palladium-catalyzed intramolecular asymmetric allylic alkylation

Creators

Abstract

A Pd(0)-catalyzed intramolecular allylic alkylation in the presence of (R)-3,5-t-Bu-MeOBIPHEP takes place in up to 92:8 er in agreement with DFT calculations and provides easy access to enantioenriched disubstituted γ-lactams.

Additional Information

© 2009 Georg Thieme Verlag. Received: 13 February 2009; publication Date: 04 May 2009 (eFirst); 03 June 2009 (Print). CNRS and UPMC are acknowledged for financial support. The sponsorship of COST Action D40 'Innovative Catalysis: New Processes and Selectivities' is kindly acknowledged. PF thanks the Carlsberg and Lundbeck foundations for financial support. We thank Solvias for a gift of ligands, Prof. P. S. Pregosin for a sample of ligand L5, Prof. J.-P. Genêt for a sample of ligand L3, and Prof. P.-O. Norrby for fruitful discussions.

Attached Files

Published - Bantreil2009p4729Synlett.pdf

Files

Bantreil2009p4729Synlett.pdf

Files (153.7 kB)

Name Size
md5:e7a0a299ac5c48564cd91964e768398a
153.7 kB Preview Download

Additional details

Identifiers

Eprint ID
14724
Resolver ID
CaltechAUTHORS:20090729-121619864

Funding

Centre National de la Recherche Scientifique (CNRS)
Université Pierre et Marie Curie
Carlsberg Foundation
Lundbeck Foundation

Dates

Created
2009-08-07
Created from EPrint's datestamp field
Updated
2021-11-08
Created from EPrint's last_modified field