CaltechAUTHORS
Published April 15, 2013 | Version public
Journal Article Metadata-only

Development of functional assays for p97/VCP inhibition

Creators

  • 1. ROR icon SRI International
  • 2. ROR icon University of California, Los Angeles
  • 3. ROR icon California Institute of Technology

Abstract

p97 (also called VCP in metazoans and CDC48 in yeast) is a highly conserved, ubiquitously expressed, and essential AAA ATPase. p97 plays a key role in endoplasmic reticulum-associated degradation of misfolded secretory and membrane proteins as well as ubiquitin-dependent turnover of a subset of cytoplasmic substrates of the ubiquitin-proteasome system.

Additional Information

© 2013 American Association for Cancer Research. Funded by NExT Chemical Biology Consortium, NCI Contract No. HHSN261200800001E.

Additional details

Identifiers

Eprint ID
44489
DOI
10.1158/1538-7445.AM2013-2146
Resolver ID
CaltechAUTHORS:20140325-082556135

Funding

NExT Chemical Biology Consortium
National Cancer Institute
HHSN261200800001E

Dates

Created
2014-03-25
Created from EPrint's datestamp field
Updated
2021-11-10
Created from EPrint's last_modified field