Metal nanoparticle alters adenine induced charge transfer kinetics of vitamin K3 in magnetic field
Creators
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1.
Indian Institute of Technology Patna
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2.
Saha Institute of Nuclear Physics
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3.
Texas A&M University
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4.
California Institute of Technology
Abstract
In this article, we highlight the alterations in the photoinduced electron transfer (ET) and hydrogen atom transfer (HAT) pathways between an anti-tumor drug vitamin-K3 (MQ) and a nucleobase adenine (ADN) in the presence of gold (Au) and iron (Fe) nanoparticles (NPs). Inside the confined micellar media, with laser flash photolysis corroborated with an external magnetic field (MF), we have detected the transient geminate radicals of MQ and ADN, photo-generated through ET and HAT. We observe that the presence of AuNP on the MQ-ADN complex (^(Au)MQ-ADN) assists HAT by limiting the ET channel, on the other hand, FeNP on the MQ-ADN complex (^(Fe)MQ-ADN) mostly favors a facile PET. We hypothesize that through selective interactions of the ADN molecules with AuNP and MQ molecules with FeNP, a preferential HAT and PET process is eased. The enhanced HAT and PET have been confirmed by the escape yields of radical intermediates by time-resolved transient absorption spectroscopy in the presence of MF.
Additional Information
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Received 29 July 2020; Accepted 28 September 2020; Published 28 October 2020. The authors acknowledge the Science and Engineering Research Board, Govt. of India, for Research grant under sanction ECR/2016/002036. RKB, SK, and LM acknowledge fellowships from IIT Patna and SERB respectively. Author Contributions: R.K.B., A.S., M.K.S. and S.B. conceived the basic idea and designed the experiments. R.K.B., K.B. and A.S. prepared the nanomaterial and performed the spectroscopic characterization and laser flash photolysis, R.K.B., A.S., L.M., K.B., S.M., S.B. and M.K.S. analyzed and discussed the results. Convolution measurements were performed by S.K. and M.K.S. All authors contributed in the preparation of the manuscript. Competing interests: The authors declare no competing interests.Attached Files
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Supplemental Material - 41598_2020_75262_MOESM1_ESM.pdf
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41598_2020_75262_MOESM1_ESM.pdf
Additional details
Identifiers
- PMCID
- PMC7595215
- Eprint ID
- 106390
- Resolver ID
- CaltechAUTHORS:20201103-101606838
Funding
- Science and Engineering Research Board (SERB)
- ECR/2016/002036
- Indian Institute of Technology Patna
Dates
- Created
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2020-11-04Created from EPrint's datestamp field
- Updated
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2021-11-16Created from EPrint's last_modified field